Title: TBA
Abstract: TBA

Title: Physiologically Based Pharmacokinetic Models and Applications in Chemical Risk Assessments
Abstract: Because many observable health effects associated with chemical exposures are believed to be more directly related to internal measures of dose (e.g., tissue concentration) than to external ones (e.g., amount ingested), the chemical risk assessment process often involves translating applied doses or environmental exposures into internal dose metrics. Physiologically based pharmacokinetic (PBPK) models, which use systems of ordinary differential equations to describe the biological processes of absorption, distribution, metabolism, and excretion, provide a means for calculating internal dose metrics. PBPK models can also be used to compare and combine data from toxicological studies that involve different animal species, different dosing regimens, and different routes of exposure, and to estimate human exposure levels that result in internal doses associated with adverse health outcomes. Thus, PBPK models can be used to support chemical risk assessments in a variety of ways. This presentation will include a description of the fundamental concepts underlying PBPK modeling and a discussion of applications of PBPK models in human health chemical risk assessments such as those conducted by the Integrated Risk Information System (IRIS) Program of the U.S. Environmental Protection Agency.

Title: Population Dynamics in Applied Ecology: Models & Experiments
Abstract: Understanding how and why populations are regulated is a central concern in applied ecology. Mathematical models, especially those parameterized with field- and laboratory- derived data, are a powerful tool for understanding population dynamics and the forces governing population regulation. I describe several examples taken from nearly two decades of collaborative research with the H.T. Banks lab in which field/lab data from ecological experiments were incorporated into population models in order to estimate parameters and derive insights into drivers of population dynamics in applied ecology. Ecological research case studies include topics ranging from tropical forest bird conservation to the support of ecosystem services such as pest control and pollination in agricultural systems.