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                                                                          The cardiovascular dynamics group is focused on studying the cardiovascular system and its interaction with other systems within the body. Projects include understanding how the vasculature remodel in patients with pulmonary hypertension, if and why patients with Postural Orthostatic Tachycardia  (POTS) exhibit an attenuated baroreflex response, and how the inflammatory response associated with sepsis impacts cardiovascular dynamics. 

Specific emphasis is to develop new tools integrating modeling and data analysis to better interpret and understand disease. We do so by building mathematical models derived from analysis of physiological principles ranging from cell to organs. To fit models to data and assess what model is the most appropriate we integrate all models in a statistical framework using both frequentist and Bayesian methodology. Check out some of our research topics below.

Core Research

 Autonomic Dysfunction                   Fontan Circulation                       Inflammation                      Pulmonary Hypertension



Recent Publications


Persistent instability in a nonhomogeneous delay differential equation system of the Valsalva maneuver
Randall, E. B., Randolph N. Z., Olufsen, M. S.
Math Biosci, 2020

Characterization of blood pressure and heart rate oscillations of POTS patients via uniform phase empirical mode decomposition
Geddes, J. R., Mehlsen, J., Olufsen, M. S.
IEEE Trans Biomed Eng, 2020

Deep phenotyping of cardiac function in heart transplant patients using cardiovascular systems models
Colunga, A. L., Kim, K. G., Woodall, N. P., Gennari, J. H., Olufsen, M. S., Carlson, B. E.
                                   J Physiol, 2020

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