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                                                                           The cardiovascular dynamics group is focused on studying the cardiovascular system and its interaction with other systems within the body. Projects include understanding how the vasculature remodel in patients with pulmonary hypertension, if and why patients with Postural Orthostatic Tachycardia  (POTS) exhibit an attenuated baroreflex response, and how the inflammatory response associated with sepsis impacts cardiovascular dynamics. 

Specific emphasis is to develop new tools integrating modeling and data analysis to better interpret and understand disease. We do so by building mathematical models derived from analysis of physiological principles ranging from cell to organs. To fit models to data and assess what model is the most appropriate we integrate all models in a statistical framework using both frequentist and Bayesian methodology. Check out some of our research topics below.

Core Research

                                                Autonomic Dysfunction                   Fontan Circulation                       Inflammation                                   

    Parameter Estimation & Uncertainty Quantification         Pulmonary Hypertension



Recent Publications


Parameter inference in a computational model of hemodynamics in pulmonary hypertension
Colebank, M.J.*, Colunga, A.L.*, King, M., Schell, C., Sheldon, M., Kharbat, M., Sternquist, R., Olufsen, M.S., (* contributed equally), In review, Preprint arXiv:2101.06266 [q-bio.QM], 2021

Global sensitivity analysis informed model reduction and selection applied to a Valsalva maneuver model
Randall, E.B., Randolph, N.Z., Alexanderian, A., Olufsen, M.S., Preprint arXiv:2005.121879[q-bio.QM], 2020

A physiological model of the inflammatory-thermal-pain-cardiovascular interactions during a pathogen challenge
Dobreva, A., Brady, R., Larripa, K., Puelz, C., Mehlsen, J., Olufsen, M.S., J Physiol,                                        2020

 

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