The Cardiovascular Dynamics Group is focused on studying the cardiovascular system and its interaction with other systems within the body. Projects include understanding the vasculature remodel in patients with pulmonary hypertension, if and why patients with Postural Orthostatic Tachycardia (POTS) exhibit an attenuated baroreflex response, and how the inflammatory response associated with sepsis impacts cardiovascular dynamics. Specific emphasis is to develop new tools integrating modeling and data analysis to better interpret and understand diseases and illnesses. We do so by building mathematical models derived from analysis of physiological principles ranging from cells to organs. To fit models to data and assess what model is the most appropriate, we integrate all models in a statistical framework using both frequentist and Bayesian methodology. Check our research topics in further depth by clicking here!
Parameter inference in a computational model of hemodynamics in pulmonary hypertension
Colebank, M.J.*, Colunga, A.L.*, King, M., Schell, C., Sheldon, M., Kharbat, M., Sternquist, R., Olufsen, M.S., (* contributed equally), Submitted, Preprint arXiv:2101.06266 [q-bio.QM], 2021
Classification of orthostatic intolerance through data analytics
Gilmore, S., Hart, J., Geddes, J., Olsen, C.H., Mehlsen, J., Gremaud, P., Olufsen, M.S., Med Biol Eng Comput (Accepted), 2021
A physiological model of the inflammatory-thermal-pain-cardiovascular interactions during a pathogen challenge
Dobreva, A., Brady, R., Larripa, K., Puelz, C., Mehlsen, J., Olufsen, M.S., J Physiol, 2021.
This publication is featured in The Journal of Physiology Virtual Journal Club.
NEWS & UPCOMING EVENTS
- Mathematics Summer 2021 REU, May 23 – July 31, 2021. The Mathematics Department of North Carolina State University is holding its Research Experiences for Undergraduates (REU) program. Click here for more information on the 2021 program!
- Conference Presentations: Come See Us!
- Congratulations to Mitchel Colebank for successfully defending his Ph.D. dissertation titled Computational Modeling of Patient Specific Pulmonary Hemodynamics (March 2021). Click here to view a recording of his defense!
- Congratulations to Alyssa Taylor for being awarded a 2021 National Science Foundation (NSF) Graduate Research Fellowship (GRF)
- Congratulations to Chris Schell for being awarded for being awarded the 2020-2021 Outstanding Research Award in the Mathematics Department for graduating seniors.