The cardiovascular dynamics group is focused on studying the cardiovascular system and its interaction with other systems within the body. Projects include understanding how the vasculature remodel in patients with pulmonary hypertension, if and why patients with Postural Orthostatic Tachycardia  (POTS) exhibit an attenuated baroreflex response, and how the inflammatory response associated with sepsis impacts cardiovascular dynamics. 

Specific emphasis is to develop new tools integrating modeling and data analysis to better interpret and understand disease. We do so by building mathematical models derived from analysis of physiological principles ranging from cell to organs. To fit models to data and assess what model is the most appropriate we integrate all models in a statistical framework using both frequentist and Bayesian methodology. Check out some of our research topics below.

Core Research

                                                Autonomic Dysfunction                   Fontan Circulation                       Inflammation                                        Parameter Estimation & Uncertainty Quantification         Pulmonary Hypertension

Recent Publications

Structural and hemodynamic properties of murine pulmonary arterial networks under hypoxia-induced pulmonary hypertension
Chambers, M.J., Colebank, M.J., Qureshi, M.U., Clipp, R., Olufsen, M.S.,
                                    J Engineering in Medicine, 2020

Multi-Linear Population Analysis (MLPA) of LFP data using Tensor Decompositions
Geddes, J., Einevoll, G.T., Acar, E. and Stasik, A.J., Frontiers in Applied Mathematics and Statistics, 2020

Persistent instability in a nonhomogeneous delay differential equation system of the Valsalva maneuver
Randall, E. B., Randolph N. Z., Olufsen, M. S.,Math Biosci, 2020



Upcoming Events

  • Joint Mathematics Meetings (JMM), January 6-9, 2021.
  • Mathematics Summer REU, May 25 - August 1, 2020. The Mathematics Department of North Carolina State University is holding its Research Experiences for Undergraduates (REU) program. Click here to see presentations by the REU students at the Math REU Conference held by Clemson University on July 27, 2020.
  • SIAM LS Virtual Minisymposia, June 2, 2020, Analysis of physiological data (Part I-III - MS62,MS73,MS83). To see a full list of speakers and topics, click here.

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